Syntheses of Anisomycin Derivatives
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چکیده
The structure of anisomycin has been determined by X-ray investigation4 and the absolute configuration was confirmed by chemical correlation.5 Anisomycin has attracted considerable synthetic interest, and several synthetic studies, derivative syntheses as well as total syntheses, have been reported.6 Especially, the synthesis of its analogues has revealed the structure-activity relationship of the synthetic antibiotics.7 As we are interested in the effect of chain extension of the p-methoxybenzyl group in the molecule, we have developed a new synthetic approach to the anisomycin related compounds. In this approach, stereoselective cis-amidoalkylation has been employed to requisite intermediates.8 Here, we disclose the details of the syntheses of the derivatives.
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تاریخ انتشار 1999